| basic FUNCTION
| plays crucial roles in the development and function of the reproductive, visual, and nervous systems |
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metalloproteinase inducer involved in cell recognition |
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playing a role in normal retinal development and maturation |
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may be playing a role in atherosclerosis development |
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stimulating fibroblasts to synthetize matrix metalloproteinases |
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signaling receptor for cyclophilin B (PPIB) |
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MMP modulator in cancer, development and tissue repair |
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plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression |
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via the selective inhibition of specific downstream elements of the Vav1/Rac1 route, contributes to the negative regulation of T-cell responses |
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promotes invasion and metastasis in different tumor types via the induction of MMPs4 and the urokinase-type plasminogen activator system by peritumoral stromal cells |
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stimulates production of matrix metalloproteinases |
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influences beta-amyloid levels by an indirect mechanism involving MMPs that can degrade extracellular beta-amyloid |
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functions in cell adhesion as an inducer of matrix metalloproteinase (MMP) expression in surrounding cells |
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in the myocardium the regulated expression of EMMPRIN is a determinant of MMP activity and may thus play a role in myocardial remodeling  |
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involved in several aspects of tumor progression and in addition to its ability to induce vascular endothelial growth factor (VEGF) production, it confers resistance to some chemotherapeutic drugs |
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plays a key regulatory role for MMP activities |
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has a central role in lung tumor progression through its ability to enhance cell proliferation, migration, anchorage-independent growth and cell survival |
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has a fundamental role in tumorigenesis by its ability to regulate Wnt/beta-catenin signaling in cancer |
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regulator of leukocyte transmigration into the CNS in multiple sclerosis |
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is a mediator of trophoblast functions |
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function of basigin in thymus development |
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BSG and ADAM12 play a major role in cancer invasion and metastasis owing to the fact that they are directly related to the cell microenvironment and extracellular matrix (ECM) degradation |
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roles in cellular functions, such as migration, adhesion, invasion, energy metabolism, as well as T cell activation and proliferation |
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may promote liver fibrosis progression via inducing the VEGF-A/KDR signalling pathway-mediated cross-talk between hepatocytes and SECs (sinusoidal endothelial cells) |
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is a central player in tumor progression and predicts a poor prognosis |
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BSG from hypoxic microglia plays a pivotal pro-angiogenic role, providing new insights into microglia-promoting retinal angiogenesis |
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BSG -induced cell proliferation is associated with SMAD4 signal inhibition |
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represents the first HCMV entry mediator that specifically functions to promote entry of pentamer-expressing HCMV into epithelial and endothelial cells |
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plays an important role in germ cells migration and survival/apoptosis during the spermatogenesis process |
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has an important role in the regulation of germ cells apoptosis via a MMPs-dependent pathway |
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BSG may be involved in a physiological positive feedback loop that accelerates podocyte cell motility and depolarization |
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tumor-associated antigen that plays a key regulatory role in tumor invasion and distant metastasis |
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mediates leukocyte aggregation which is associated with the development of liver injury, and and determines the extent of liver injury |
