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FLASH GENE

Symbol

CD58

contributors: mct/npt - updated : 03-06-2009

HGNC name	CD58 molecule
HGNC id	1688

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   is seen during the clinically quiescent phase of multiple sclerosis (MS) and, finally, higher CD58 expression may function in part by enhancing FOXP3 expression in regulatory T cells (De Jager 2009)

Susceptibility

to multiple sclerosis (MS)

Variant & Polymorphism other	association of allelic variants in the CD58 gene with MS susceptibility

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS