Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CD58 contributors: mct/npt - updated : 03-06-2009
HGNC name CD58 molecule
HGNC id 1688
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two extracellular Ig-like domains
  • six N-linked glycosylation sites
  • a hydrophobic putative transmembrane (TM) region
  • a short cytoplasmic domain
    • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to CD2
    Homologene
    FAMILY
  • Ig superfamily
    • CATEGORY adhesion , antigen , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text attached to the membrane by a GPI anchor
    basic FUNCTION
  • interaction between CD2 and CD58 on opposing cells optimizes immune recognition
  • enhancing signal-dependent adhesion of resting NK cells initiated by expression of ICAM1
  • adhesion molecule involved in intercellular adhesion and in signal transduction (Ariel 2004)
  • costimulates and enhances T cell receptor signaling by engaging CD2 (De Jager 2009)
  • complex CD2/CD58 plays an important role in enhancing the adhesion of T lymphocytes to target cells, and promoting hyperplasia and activation of T lymphocytes (Li 2008)
  • T cell activation causes the CD58-bound CD2 to be recognized and immobilized at sites of cell-cell contact, thereby strengthening T cell-APC adhesion (Zhu 2006)
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand of CD2 antigen (interaction mediating tight adhesion within the 2D cell-cell interface) (Zhu 2006)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    is seen during the clinically quiescent phase of multiple sclerosis (MS) and, finally, higher CD58 expression may function in part by enhancing FOXP3 expression in regulatory T cells (De Jager 2009)
    Susceptibility to multiple sclerosis (MS)
    Variant & Polymorphism other association of allelic variants in the CD58 gene with MS susceptibility
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS