Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CD58 contributors: mct/npt - updated : 03-06-2009
HGNC name CD58 molecule
HGNC id 1688
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 stomach   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte
Lymphoid/Immunenatural killer
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two extracellular Ig-like domains
  • six N-linked glycosylation sites
  • a hydrophobic putative transmembrane (TM) region
  • a short cytoplasmic domain
    • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to CD2
    Homologene
    FAMILY
  • Ig superfamily
    • CATEGORY adhesion , antigen , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text attached to the membrane by a GPI anchor
    basic FUNCTION
  • interaction between CD2 and CD58 on opposing cells optimizes immune recognition
  • enhancing signal-dependent adhesion of resting NK cells initiated by expression of ICAM1
  • adhesion molecule involved in intercellular adhesion and in signal transduction (Ariel 2004)
  • costimulates and enhances T cell receptor signaling by engaging CD2 (De Jager 2009)
  • complex CD2/CD58 plays an important role in enhancing the adhesion of T lymphocytes to target cells, and promoting hyperplasia and activation of T lymphocytes (Li 2008)
  • T cell activation causes the CD58-bound CD2 to be recognized and immobilized at sites of cell-cell contact, thereby strengthening T cell-APC adhesion (Zhu 2006)
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand of CD2 antigen (interaction mediating tight adhesion within the 2D cell-cell interface) (Zhu 2006)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    is seen during the clinically quiescent phase of multiple sclerosis (MS) and, finally, higher CD58 expression may function in part by enhancing FOXP3 expression in regulatory T cells (De Jager 2009)
    Susceptibility to multiple sclerosis (MS)
    Variant & Polymorphism other association of allelic variants in the CD58 gene with MS susceptibility
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS