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FLASH GENE

Symbol

CD58

contributors: mct/npt - updated : 03-06-2009

HGNC name	CD58 molecule
HGNC id	1688

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	56.45 kb     6 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Binding site
text structure	for AP2, GATA, PU1, Sp1

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	untranslated ribosomal

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 2 - - 1395 isoform 2 27.8 248 - Ariel (2004), De Jager (2009) transmembrane form residing in nonraft domains may trigger signaling independently of the GPI-linked isoform variant 1 6 - 1153 isoform 1 28 250 - Ariel (2004), De Jager (2009) GPI-anchored form localized in lipid rafts (Ariel 2004) constitutively associated with protein kinases

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly   stomach       highly

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune lymphocyte Lymphoid/Immune natural killer Lymphoid/Immune T cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two extracellular Ig-like domains
	six N-linked glycosylation sites
	a hydrophobic putative transmembrane (TM) region
	a short cytoplasmic domain

conjugated

GlycoP

HOMOLOGY

intraspecies

homolog to CD2

Homologene

FAMILY

Ig superfamily

CATEGORY

adhesion , antigen , receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane
text	attached to the membrane by a GPI anchor

basic FUNCTION	interaction between CD2 and CD58 on opposing cells optimizes immune recognition
	enhancing signal-dependent adhesion of resting NK cells initiated by expression of ICAM1
	adhesion molecule involved in intercellular adhesion and in signal transduction (Ariel 2004)
	costimulates and enhances T cell receptor signaling by engaging CD2 (De Jager 2009)
	complex CD2/CD58 plays an important role in enhancing the adhesion of T lymphocytes to target cells, and promoting hyperplasia and activation of T lymphocytes (Li 2008)
	T cell activation causes the CD58-bound CD2 to be recognized and immobilized at sites of cell-cell contact, thereby strengthening T cell-APC adhesion (Zhu 2006)

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

ligand of CD2 antigen (interaction mediating tight adhesion within the 2D cell-cell interface) (Zhu 2006)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   is seen during the clinically quiescent phase of multiple sclerosis (MS) and, finally, higher CD58 expression may function in part by enhancing FOXP3 expression in regulatory T cells (De Jager 2009)

Susceptibility

to multiple sclerosis (MS)

Variant & Polymorphism other	association of allelic variants in the CD58 gene with MS susceptibility

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS