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FLASH GENE
Symbol CD58 contributors: mct/npt - updated : 03-06-2009
HGNC name CD58 molecule
HGNC id 1688
Location 1p13.1      Physical location : 117.057.156 - 117.113.715
Synonym name
  • CD58 antigen, (lymphocyte function-associated antigen 3)
  • lymphocyte function-associated antigen 3
  • cell differentiation antigen CD58 (LFA-3), identified by monoclonal antibodies G26, BRIC5, TS2/9, T cell restricted CD2 ligand
  • surface glycoprotein LFA-3
    • Synonym symbol(s) LFA3, Ag3
    DNA
    TYPE functioning gene
    STRUCTURE 56.45 kb     6 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    text structure for AP2, GATA, PU1, Sp1
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type untranslated ribosomal
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1395 27.8 248 - Ariel (2004), De Jager (2009)
  • transmembrane form residing in nonraft domains
  • may trigger signaling independently of the GPI-linked isoform
    • 6 - 1153 28 250 - Ariel (2004), De Jager (2009)
  • GPI-anchored form localized in lipid rafts (Ariel 2004)
  • constitutively associated with protein kinases
    		•
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     stomach   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    Lymphoid/Immunenatural killer
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two extracellular Ig-like domains
  • six N-linked glycosylation sites
  • a hydrophobic putative transmembrane (TM) region
  • a short cytoplasmic domain
    • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to CD2
    Homologene
    FAMILY
  • Ig superfamily
    • CATEGORY adhesion , antigen , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text attached to the membrane by a GPI anchor
    basic FUNCTION
  • interaction between CD2 and CD58 on opposing cells optimizes immune recognition
  • enhancing signal-dependent adhesion of resting NK cells initiated by expression of ICAM1
  • adhesion molecule involved in intercellular adhesion and in signal transduction (Ariel 2004)
  • costimulates and enhances T cell receptor signaling by engaging CD2 (De Jager 2009)
  • complex CD2/CD58 plays an important role in enhancing the adhesion of T lymphocytes to target cells, and promoting hyperplasia and activation of T lymphocytes (Li 2008)
  • T cell activation causes the CD58-bound CD2 to be recognized and immobilized at sites of cell-cell contact, thereby strengthening T cell-APC adhesion (Zhu 2006)
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand of CD2 antigen (interaction mediating tight adhesion within the 2D cell-cell interface) (Zhu 2006)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    is seen during the clinically quiescent phase of multiple sclerosis (MS) and, finally, higher CD58 expression may function in part by enhancing FOXP3 expression in regulatory T cells (De Jager 2009)
    Susceptibility to multiple sclerosis (MS)
    Variant & Polymorphism other association of allelic variants in the CD58 gene with MS susceptibility
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS