basic FUNCTION
| can mediate both Ca2+ and cAMP transcriptional responses (Liu et al, 1993) |
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mediating the E1A responsiveness |
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activating transcription factor 1 |
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having a role as a hypoxia-responsive trans-activator |
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photoreceptors degeneration leads to phosphorylation and increase expression of CREB1/ATF1 complex which is associated with a neuroprotective outcome in photoreceptors (Beltran et al, 2009) |
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markedly affected the resistance to heat shock |
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functions as an oncogene by affecting cell apoptosis, and two causal SNPs, located in the ATF1 promoter and first intron, synergistically predispose to colorectal cancer risk through a promoter-enhancer interaction mediated by SP1 and GATA3 |
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important role of ATF1 in the development of colorectal cancer |
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is a novel pluripotent regulator in human embryonic stem cells (hESCs) |