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FLASH GENE
Symbol APLP2 contributors: mct/npt - updated : 12-05-2010
HGNC name amyloid beta (A4) precursor-like protein 2
HGNC id 598
Location 11q24.3      Physical location : 129.939.715 - 130.014.705
Synonym name
  • CDEI box-binding protein
  • amyloid precursor protein homolog HSD-2
  • Synonym symbol(s) APPL2, APPH, B16D6, CDEBP
    DNA
    TYPE functioning gene
    STRUCTURE 74.90 kb     19 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 3791 - 751 - von der Kammer (1994)
    16 - 3623 - 695 - von der Kammer (1994)
    13 - 3104 - 522 - von der Kammer (1994)
    18 - 3827 - 763 - von der Kammer (1994)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveesophagus   highly
     liver    
    Endocrineparathyroid   highly
    Nervousbrain   highly
    Reproductivemale systemtestis  highly
    Respiratorylung    
     respiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet
    Cardiovascularendothelial cell
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion sperm
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a KPI domain similar to the KPI domain of APP
  • HOMOLOGY
    Homologene
    FAMILY
  • Alzheimer's amyloid precursor protein (APP)family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    intracellular,nucleus
    basic FUNCTION
  • putatively involved in the mitotic segregation of the genome and establishment of the proper nuclear structure
  • inhibiting thrombosis
  • having a putative role in sperm function (Fardilha 2007)
  • modulates the stability and endocytosis of the MHC class I molecule K(d) (Tuli 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    likewise stimulates neurite lengthening (Young-Pearse 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    mouse