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FLASH GENE
Symbol FKBP3 contributors: npt/mct - updated : 20-04-2017
HGNC name FK506 binding protein 3, 25kDa
HGNC id 3719
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal FK506 binding and peptidyl prolyl cis-trans isomerase (rotamase) domain
  • three tetratricopeptide repeat (TPR) motifs consistent nuclear transcript or chaperone activity
  • C-terminal FK506-binding domain (FKBD)
    • HOMOLOGY
    Homologene
    FAMILY
  • immunophilin class of proteins family
  • FKBP-type PPIase family
  • super-family of peptidylprolyl cis/trans isomerases
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus,chromatin/chromosome,nucleosome
    text
  • endogenous FKBP3 is associated to the core histones of the nucleosome, and with several proteins forming spliceosomal complexes and ribosomal subunits
    • basic FUNCTION
  • T cell binding protein FKBP-25 for the immunosuppressive agents FK506-rapamycin
  • intrinsic peptidyl-prolyl cis-trans isomerase activity
  • contributes to regulation of the TP53-MDM2 negative feedback loop
  • DNA-binding protein that encompasses peptidylprolyl cis–trans isomerase (PPI) activity
  • can stimulate the ability of MDM2 to undergo auto-ubiquitylation leading to its rapid degradation
  • plays an important role in regulating transcription and chromatin structure
  • catalyze the cis-trans isomerization of prolyl-peptide bonds in proteins
  • nuclear protein that has been shown to associate with chromatin modifiers and transcription factors
  • is likely recruited to preribosomes to chaperone one of the protein components of the ribosome large subunit
  • evidence for a role of immunophilins, including FKBP3 and FKBP8, in Non-capacitative calcium entry (NCCE) mediated by TRPC6
    • CELLULAR PROCESS protein, post translation, folding
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
  • cellular trafficking
  • ESD/FKBP3/MTOR signaling pathway is involved in inhibiting tumor cell growth via regulating autophagy
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with MDM2 (stimulates auto-ubiquitylation and proteasomal degradation of MDM2, leading to the induction of TP53)
  • both TREM2 and OSCAR were inhibited by FKBP3 in the late stage of osteoclast formation
  • interacts with chromatin-related proteins and transcription factors and is suggested to interact with nucleic acids
    • cell & other
    REGULATION
    inhibited by predominantly by rapamycin
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS