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FLASH GENE
Symbol MT3 contributors: mct/npt - updated : 15-07-2008
HGNC name metallothionein 3
HGNC id 7408
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a TCPCP motif, implicated in neuronal growth inhibitory activity
    • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • metallothionein superfamily
  • type 1 family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic,vesicle
    text synaptic vesicles
    basic FUNCTION
  • growth inhibitory factor, that may protect adipocytes from hypoxic damage
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • heavy metal ions, three zinc Zn2+ and four copper atomes per polypeptide chain and one cadmium
    • protein
    cell & other
    REGULATION
    induced by heavy metal ions
    highly hypoxia-inducible gene in adipocytes
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in Alzheimer's disease and neurodegenerative disease
    tumoral     --low  
    in oesophageal squamous cell carcinoma, by DNA methylation, but that this is not a prognostic indicator
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS