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FLASH GENE
Symbol MT3 contributors: mct/npt - updated : 15-07-2008
HGNC name metallothionein 3
HGNC id 7408
DNA
TYPE functioning gene
STRUCTURE 1.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 599 6.9 68 - kim (2008)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland    
Nervousbrain    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Nervouscentral   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticneutrophil
Nervousastrocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a TCPCP motif, implicated in neuronal growth inhibitory activity
    • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • metallothionein superfamily
  • type 1 family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic,vesicle
    text synaptic vesicles
    basic FUNCTION
  • growth inhibitory factor, that may protect adipocytes from hypoxic damage
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • heavy metal ions, three zinc Zn2+ and four copper atomes per polypeptide chain and one cadmium
    • protein
    cell & other
    REGULATION
    induced by heavy metal ions
    highly hypoxia-inducible gene in adipocytes
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in Alzheimer's disease and neurodegenerative disease
    tumoral     --low  
    in oesophageal squamous cell carcinoma, by DNA methylation, but that this is not a prognostic indicator
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS