Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MT3 contributors: mct/npt - updated : 15-07-2008
HGNC name metallothionein 3
HGNC id 7408
Location 16q13      Physical location : 56.623.266 - 56.624.999
Synonym name
  • metallothionein 3 (growth inhibitory factor (neurotrophic)
  • growth inhibitory factor
    • Synonym symbol(s) GRIF, GIF, GIFB
    DNA
    TYPE functioning gene
    STRUCTURE 1.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 599 6.9 68 - kim (2008)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland    
    Nervousbrain    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticneutrophil
    Nervousastrocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a TCPCP motif, implicated in neuronal growth inhibitory activity
    • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • metallothionein superfamily
  • type 1 family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic,vesicle
    text synaptic vesicles
    basic FUNCTION
  • growth inhibitory factor, that may protect adipocytes from hypoxic damage
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • heavy metal ions, three zinc Zn2+ and four copper atomes per polypeptide chain and one cadmium
    • protein
    cell & other
    REGULATION
    induced by heavy metal ions
    highly hypoxia-inducible gene in adipocytes
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in Alzheimer's disease and neurodegenerative disease
    tumoral     --low  
    in oesophageal squamous cell carcinoma, by DNA methylation, but that this is not a prognostic indicator
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS