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FLASH GENE
Symbol RPS6KB2 contributors: mct - updated : 27-10-2012
HGNC name ribosomal protein S6 kinase, 70kDa, polypeptide 2
HGNC id 10437
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two non identical catalytic domains, respectively located in N and C terminal region
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • ribosomal protein S6 kinase, not involved in the phosphorylation of RPS6, mediating protein synthesis initiation and elongation induced by hormones or growth factors
  • may be playing an essential regulatory role in protein synthesis during cell proliferation
  • plays a role in IL3-dependent cell proliferation
  • RPS6KB2 but not RPS6KB1 mediates prosurvival/chemoresistance signalling
  • play important roles in the regulation of protein synthesis, cell growth and survival
  • in addition to phosphorylation, RPS6KB1, and RPS6KB2 are also targeted by lysine acetylation
  • promotes breast cancer cell survival via AKT1
  • RPS6KB1 and RPS6KB2, are important MTOR signaling effectors, but with a differential protein expression in human tissues
    • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    ATP binding
    protein
  • RPS6 binding
  • RPS6KB1/2 phosphorylate EIF3A to stimulate PAIP1-EIF3A interaction and consequent translation initiation
    • cell & other
    REGULATION
    activated by IL3 in the IL3-dependent Ba/F3 cell line and this is mediated by MTOR and its upstream activator PI-3K but not by the MAPK kinase/extracellular signal-regulated kinase pathway
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS