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FLASH GENE
Symbol HOMER2 contributors: mct - updated : 31-03-2007
HGNC name homer homolog 2 (Drosophila)
HGNC id 17513
Location 15q24.3      Physical location : 83.517.737 - 83.621.473
Synonym name
  • cupidin
  • homer 2
  • homer homolog 3
  • homer, neuronal immediate early gene 2B
  • Synonym symbol(s) HOMER2A, HOMER2B, ACPD, CPD, HOMER-2, Vesl-2, Cupidin
    DNA
    TYPE functioning gene
    STRUCTURE 103.74 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D15S115 - HOMER2 - D15S200 - D15S152 - qter
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2005 39 354 cortex, hippocampus, olfactory bulb, cerebellum 2005 16314758
    also called HOMER2B
    9 - 1972 38 343 - 2005 16314758
  • also called HOMER2A
  • neuronal immediate early gene
  • 9 - 1807 - 288 - 2005
    also called HOMER2C
    9 - 1840 - 299 - 2005 16314758
    also called HOMER2D
    - - - - 297 - 2005 15944415
  • alsos called HOMER2B28
  • contains three major domains: a UBA domain, a coiled-coil region, and a UBX domain
  • involved in ubiquitin-proteasome functions
  • specifically interacted and colocalized with HOMER2 proteins, but not with HOMER1 proteins
  • EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinepancreas   highly
     thyroid   highly
    Nervousbrainforebraincerebral cortex  
     braindiencephalonhypothalamus  
     brainhindbraincerebellum  
    Olfactoryolfactory bulb    
    Reproductivemale systemprostate  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Muscularstriatumskeletal  
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • PDZ (PSD95/disc large/ZO-1) domains
  • a WAS homology domain (WH1), variant EVASP, interacting with the PPXXF motif
  • mono polymer homomer , oligo
    HOMOLOGY
    Homologene
    FAMILY
  • homer family of dendritic proteins
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • clustering and linking metabotropic glutamate receptors group I with the inositol triphosphate receptors regulator of GRMs signaling
  • may play a role in regulation of protein degradation by ubiquitin-proteasome systems and this function may be specific to HOMER2 proteins among HOMER family proteins
  • may be involved in cell growth
  • cooperates with MYO18B for the suppression of anchorage-independent growth
  • being a negative regulator of T cell activation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3
  • interacting with MYO18B (partly co-localize on F-actin)
  • interacting with UBXN1 (specifically interacted and colocalized with HOMER2 proteins, and this specific interaction may play a role in regulation of protein degradation by ubiquitin-proteasome systems, function that may be specific to HOMER2 among HOMER family proteins))
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS