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FLASH GENE

Symbol

HOMER1

contributors: mct/npt - updated : 23-12-2014

HGNC name	homer homolog 1 (Drosophila)
HGNC id	17512

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in spinal cord neurons after peripheral inflammation in an NMDA receptor-dependent manner constitutional     --over   after sleep deprivation and after inflammation, seizure, and psychostimulant or antipsychotic drug use, playing a major role in neuroprotection tumoral     --over   in intrahepatic cholangiocarcinoma, with a worse prognosis

Susceptibility

to psychotic symptoms in Parkinson disease (PD)

Variant & Polymorphism other	allele A of the rs4704559 marker associated to psychotic symptoms in PD (De Luca 2009)

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed miscelleaneous pain   promising therapeutic target for the treatment of chronic inflammatory pain neurology acquired   suppression of HOMER1B/C expression potentially protects neurons from glutamate excitotoxicity after injury and might be an effective intervention target in traumatic brain injury

ANIMAL & CELL MODELS