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FLASH GENE
Symbol PPP2R2B contributors: mct - updated : 08-01-2017
HGNC name protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
HGNC id 9305
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , trimer
HOMOLOGY
interspecies homolog to C.elegans F26e4.1
intraspecies homolog to PPP2R2A,PPP2R2C
Homologene
FAMILY
  • phosphatase 2a regulator subunit b family
    • CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytoskeleton
    text
  • neuronal cell bodies and dendrites
  • can localize to mitochondria
    • basic FUNCTION
  • modulating substrate selectivity and catalytic subunit (subunit c)
  • directing the localization of the catalytic enzyme to a particular subcellular compartment
  • important regulator of phosphatase activity in the brain
  • plays a crucial role in the maintenance of cell-cell adhesion through recruitment of IQGAP1 to the Rac-bound E-cadherin-catenins complex
  • predisposes to neuronal death by promoting mitochondrial division and point to a possible imbalance of the mitochondrial morphogenetic equilibrium in the pathogenesis of SCA12
  • outer mitochondrial PP2A holoenzyme that is a critical regulator of the mitochondrial morphogenetic equilibrium, and which determines the susceptibility of neurons to diverse injuries
  • regulates the protein phosphatase 2A (PP2A) activity for dephosphorylation of tau and other substrates
    • CELLULAR PROCESS cell cycle, division
    cell cycle, checkpoint
    cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text muscle contraction; implicated in IR-induced activation of check points
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    a component
  • heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (pr65 or subunit A) and associating with a variety of regulatory subunits (including three families of subunit B)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CREB1, SP1, and TFAP4 play roles in modulating PPP2R2B expression
  • PPP2R2B protein interacts with the ACVRL1/TGFBR2/ENG complex and recruits PP2A to nitric oxide synthase 3 (NOS3)
    • cell & other
    REGULATION
    Other CREB1, SP1, and TFAP4 play roles in modulating PPP2R2B expression
    ASSOCIATED DISORDERS
    corresponding disease(s) SCA12
    Susceptibility
  • to breast cancer
  • to Alzheimer disease (AD)
    • Variant & Polymorphism SNP , repeat
  • A variant of the rs319217 SNP is a marker of better prognosis in breast cancer
  • CAG repeat lengths in the PPP2R2B gene may be potential genetic markers for AD susceptibility in the Japanese population
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS