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FLASH GENE

Symbol

PPP2R2B

contributors: mct - updated : 08-01-2017

HGNC name	protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
HGNC id	9305

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       specific Visual eye retina

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens Nervous Purkinje cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

heteromer , trimer

HOMOLOGY

interspecies

homolog to C.elegans F26e4.1

intraspecies

homolog to PPP2R2A,PPP2R2C

Homologene

FAMILY

phosphatase 2a regulator subunit b family

CATEGORY

enzyme , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,outer
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,cytoskeleton
text	neuronal cell bodies and dendrites
	can localize to mitochondria

basic FUNCTION	modulating substrate selectivity and catalytic subunit (subunit c)
	directing the localization of the catalytic enzyme to a particular subcellular compartment
	important regulator of phosphatase activity in the brain
	plays a crucial role in the maintenance of cell-cell adhesion through recruitment of IQGAP1 to the Rac-bound E-cadherin-catenins complex
	predisposes to neuronal death by promoting mitochondrial division and point to a possible imbalance of the mitochondrial morphogenetic equilibrium in the pathogenesis of SCA12
	outer mitochondrial PP2A holoenzyme that is a critical regulator of the mitochondrial morphogenetic equilibrium, and which determines the susceptibility of neurons to diverse injuries
	regulates the protein phosphatase 2A (PP2A) activity for dephosphorylation of tau and other substrates

CELLULAR PROCESS	cell cycle, division
	cell cycle, checkpoint
	cell life, proliferation/growth
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

text	muscle contraction; implicated in IR-induced activation of check points

PATHWAY

metabolism

signaling

sensory transduction/vision

a component

heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (pr65 or subunit A) and associating with a variety of regulatory subunits (including three families of subunit B)

INTERACTION

DNA

RNA

small molecule

protein	CREB1, SP1, and TFAP4 play roles in modulating PPP2R2B expression
	PPP2R2B protein interacts with the ACVRL1/TGFBR2/ENG complex and recruits PP2A to nitric oxide synthase 3 (NOS3)

cell & other

REGULATION

Other

CREB1, SP1, and TFAP4 play roles in modulating PPP2R2B expression

ASSOCIATED DISORDERS

corresponding disease(s)

SCA12

Susceptibility

to breast cancer to Alzheimer disease (AD)

Variant & Polymorphism SNP , repeat	A variant of the rs319217 SNP is a marker of better prognosis in breast cancer
	CAG repeat lengths in the PPP2R2B gene may be potential genetic markers for AD susceptibility in the Japanese population

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS