Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PPP2R2B contributors: mct - updated : 08-01-2017
HGNC name protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
HGNC id 9305
Corresponding disease
SCA12 spinocerebellar ataxia 12
Location 5q32      Physical location : 145.969.069 - 146.461.033
Synonym name
  • PP2A, subunit B, B-beta isoform
  • PP2A, subunit B, B55-beta isoform
    • Synonym symbol(s) PP2AB55B, PR55 beta, PR2AB-BETA, PR2AB55-BETA, SCA12
    EC.number 3.1.3.16
    DNA
    TYPE functioning gene
    STRUCTURE 491.97 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure a polymorphic CAG repeat in the 5' utr promoter region
    MAPPING cloned Y linked   status provisional
    Map cen - D5S436 - PPP2R2B - D5S470- qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 splicing 2300 - 443 - 2009 20017961
  • also called variant 1/isoform a
  • regulatory subunit isoforms that determine cellular distribution of the neuron-specific holoenzyme to cytoplasm (Bbeta1)
  • neuron-specific regulatory subunits of the protein phosphatase 2A (PP2A) holoenzyme
  • an exclusively cytoplasmic protein
    • 10 splicing 2376 - 443 - 2009 20017961
  • also called variant 2/isoform a
  • regulatory subunit isoforms that determine cellular distribution of the neuron-specific holoenzyme to mitochondria (Bbeta2)
  • neuron-specific regulatory subunits of the protein phosphatase 2A (PP2A) holoenzyme
  • in hippocampal neurons, cell stressors induced a rapid translocation of PP2A/Bbeta2 to mitochondria to promote apoptosis
  • is normally localized to both cytosol and mitochondria
    • 10 - 2077 - 443 - 2006 16475161
    also called variant 3/isoform a
    9 - 2182 - 446 - 2006 16475161
    also called variant 4/isoform b
    11 - 2008 - 423 - 2006 16475161
    also called variant 5/isoform c
    11 - 2021 - 432 - 2006 16475161
    also called variant 6/isoform d
    10 - 2097 - 443 - -
    also called variant 7/isoform a
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   specific
    Visualeyeretina   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    NervousPurkinje cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to C.elegans F26e4.1
    intraspecies homolog to PPP2R2A,PPP2R2C
    Homologene
    FAMILY
  • phosphatase 2a regulator subunit b family
    • CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytoskeleton
    text
  • neuronal cell bodies and dendrites
  • can localize to mitochondria
    • basic FUNCTION
  • modulating substrate selectivity and catalytic subunit (subunit c)
  • directing the localization of the catalytic enzyme to a particular subcellular compartment
  • important regulator of phosphatase activity in the brain
  • plays a crucial role in the maintenance of cell-cell adhesion through recruitment of IQGAP1 to the Rac-bound E-cadherin-catenins complex
  • predisposes to neuronal death by promoting mitochondrial division and point to a possible imbalance of the mitochondrial morphogenetic equilibrium in the pathogenesis of SCA12
  • outer mitochondrial PP2A holoenzyme that is a critical regulator of the mitochondrial morphogenetic equilibrium, and which determines the susceptibility of neurons to diverse injuries
  • regulates the protein phosphatase 2A (PP2A) activity for dephosphorylation of tau and other substrates
    • CELLULAR PROCESS cell cycle, division
    cell cycle, checkpoint
    cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text muscle contraction; implicated in IR-induced activation of check points
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    a component
  • heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (pr65 or subunit A) and associating with a variety of regulatory subunits (including three families of subunit B)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CREB1, SP1, and TFAP4 play roles in modulating PPP2R2B expression
  • PPP2R2B protein interacts with the ACVRL1/TGFBR2/ENG complex and recruits PP2A to nitric oxide synthase 3 (NOS3)
    • cell & other
    REGULATION
    Other CREB1, SP1, and TFAP4 play roles in modulating PPP2R2B expression
    ASSOCIATED DISORDERS
    corresponding disease(s) SCA12
    Susceptibility
  • to breast cancer
  • to Alzheimer disease (AD)
    • Variant & Polymorphism SNP , repeat
  • A variant of the rs319217 SNP is a marker of better prognosis in breast cancer
  • CAG repeat lengths in the PPP2R2B gene may be potential genetic markers for AD susceptibility in the Japanese population
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS