Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ANXA8 contributors: mct - updated : 30-03-2016
HGNC name annexin A8
HGNC id 546
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a relatively short N terminus
  • a C terminal "core" region made of four repeats homolog to the endonexin fold
    • HOMOLOGY
    interspecies homolog to murine Anxa8
    Homologene
    FAMILY
  • calcium dependent phospholipid binding protein family
    • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • vascular anticoagulation, indirect inhibitor of the thromboplastin specific complex involved in blood coagulation cascade
  • regulates late endosome organization and function
  • is a gene strongly induced late in osteoclast differentiation and a protein that regulates formation of the cell characteristic actin ring
  • might play an important role in calcium fluctuation-mediated HIF1A transcriptional activation and cell viability
  • controls leukocyte recruitment to activated endothelial cells via cell surface delivery of CD63
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • Ca2+
  • phospholipid
    • protein
  • ANXA2, ANXA8, and ANXA9 interacted with proAREG and ADAM17 on the cell surface
  • ANXA2, ANXA8, ANXA9, play an essential role in the ADAM17-mediated ectodomain shedding of EGFR ligands
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer
    tumoral     --other  
    ectopically expressed in pancreatic cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • both KRT19 and ANXA8 mRNA may be useful markers for detecting lymph node metastases in OSCC (oral squamous cell carcinoma) patients
    • Therapy target
    ANIMAL & CELL MODELS
  • Anxa8 expression in the mouse mammary gland was strong during pre-puberty before the expansion of the rudimentary ductal network and was limited to a distinct subpopulation of ductal luminal epithelial cells