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FLASH GENE

Symbol

SHROOM1

contributors: mct - updated : 26-10-2011

HGNC name	shroom family member 1
HGNC id	24084

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in pulmonary arterial hypertension suggesting a link between SHROOM1 expression and pulmonary arterial smooth muscle cell hypertrophy in pulmonary arterial hypertension (

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

mutated in mouse Shrm causing exencepaly, acrania, facial clefting and spina bifida, all of wich can be attributed to failes neural tube closure