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FLASH GENE
Symbol SGCA contributors: mct/npt - updated : 14-06-2008
HGNC name sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
HGNC id 10805
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies ortholog to murine Sgca
Homologene
FAMILY
  • sarcoglycan alpha/epsilon family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton
    text
  • sarcolemma
  • type I membrane protein
    • basic FUNCTION
  • playing a role in muscle contraction
  • forming a link between the F-actin cytoskeleton and the extracellular matrix
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text muscular development
    PATHWAY
    metabolism
    signaling
    a component
  • associating with other sarcoglycans and carcospan in a stoichiometrically equal complex, stabilizing the link between dystroglycan and dystrophin/utrophin
  • two major subcomplexes : one consisting of SGCB, SGCD and SGCG and the other consisiting of SGCB and SGCD (association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans)
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • dystrophin
  • syntrophin SNTA1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LGMD2D
    related resource Limb-Girdle Muscular Dystrophy, Type 2D
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS