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FLASH GENE

Symbol

FCGR3A

contributors: mct/npt - updated : 04-09-2017

HGNC name	Fc fragment of IgG, low affinity IIIa, receptor for (CD16)
HGNC id	3619

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

IMD20

Susceptibility

to systemic lupus erythematosus (SLE) to viral infections, recurrent and neutropenia, alloimmune neonatal to Takayasu arteritis to HIV infection and progression to immune thrombocytopenia (ITP)

Variant & Polymorphism other	genetic association between Takayasu arteritis and the FCGR2A/FCGR3A locus
	homozygous for the high activity allele of FCGR3A (158VV) were predominantly found among HIV progressors and this group was also skewed toward higher allele frequencies for the V158 variant
	FCGR3A (158V/F) polymorphism, known to increase the affinity of FCGR3A to IgG, was over-represented in ITP patients

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS