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FLASH GENE
Symbol FCGR3A contributors: mct/npt - updated : 04-09-2017
HGNC name Fc fragment of IgG, low affinity IIIa, receptor for (CD16)
HGNC id 3619
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal sequence, two Ig-like extracellular domain
  • a single transmembrane (TM) domain (TM1)
  • a protein kinase C (PKC) phosphorylation consensus motif [RSSTR], pecifically phosphorylated by PKCs
  • a short cytoplasmic tail whose expression at the cell surface depends on association with the signaling adaptor molecules CD247 and/or FCER1G
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY immunity/defense , antigen , receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • mediating antibody-dependent cellular cytotoxicity and other antibody-dependent responses, such as phagocytosis
  • plays a prominent role in the elimination of tumor cells by antibody-based cancer therapies
  • is involved in the pathogenesis of coronary heart disease (CHD) by activating monocytes and stimulating inflammation
  • role for FCGR3B in the removal of soluble immune complexes within the vasculature that may serve to maintain homeostasis
  • FCGR3A and PRF1 may participate in the pathogenesis and progression of primary biliary cirrhosis (PBC)
  • shedding of FCGR3A/CD16A was at least partially ADAM17 dependent, and it may be considered as a marker of FCGR3A/CD16A-independent NK cell activation highly correlated with degranulation
  • FCGR3A, FCGR3B are IgG Fc receptors expressed by human natural killer (NK) cells and neutrophils, respectively
  • association of the adaptor modules FCER1G or CD247 with FCGR3A not only is required for progression of this receptor through the secretory pathway and cell surface expression but also protects the FCGR3A protein from degradation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • over-activation of ADAM17 in NK cells may be detrimental to their effector functions by down-regulating surface expression of FCGR3A and SELL
  • MMP25 is a proteinase responsible for FCGR3A downmodulation
  • FCGR3A cleavage by ADAM17, but non-cleavable version of FCGR3A can be expressed in engineered NK cells (
  • expression of the FCGR3A depends on a noncovalent association with the signaling dimers FCER1G and/or CD247
  • FCGR3A requires association with adaptor modules for cell surface expression but shows no preference for assembly with either CD247 or FCER1G
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) IMD20
    Susceptibility
  • to systemic lupus erythematosus (SLE)
  • to viral infections, recurrent and neutropenia, alloimmune neonatal
  • to Takayasu arteritis
  • to HIV infection and progression
  • to immune thrombocytopenia (ITP)
    • Variant & Polymorphism other
  • genetic association between Takayasu arteritis and the FCGR2A/FCGR3A locus
  • homozygous for the high activity allele of FCGR3A (158VV) were predominantly found among HIV progressors and this group was also skewed toward higher allele frequencies for the V158 variant
  • FCGR3A (158V/F) polymorphism, known to increase the affinity of FCGR3A to IgG, was over-represented in ITP patients
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS