basic FUNCTION
| mediating antibody-dependent cellular cytotoxicity and other antibody-dependent responses, such as phagocytosis |
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plays a prominent role in the elimination of tumor cells by antibody-based cancer therapies ![](pubmed.jpg) |
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is involved in the pathogenesis of coronary heart disease (CHD) by activating monocytes and stimulating inflammation ![](pubmed.jpg) |
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role for FCGR3B in the removal of soluble immune complexes within the vasculature that may serve to maintain homeostasis ![](pubmed.jpg) |
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FCGR3A and PRF1 may participate in the pathogenesis and progression of primary biliary cirrhosis (PBC) |
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shedding of FCGR3A/CD16A was at least partially ADAM17 dependent, and it may be considered as a marker of FCGR3A/CD16A-independent NK cell activation highly correlated with degranulation ![](pubmed.jpg) |
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FCGR3A, FCGR3B are IgG Fc receptors expressed by human natural killer (NK) cells and neutrophils, respectively ![](pubmed.jpg) |
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association of the adaptor modules FCER1G or CD247 with FCGR3A not only is required for progression of this receptor through the secretory pathway and cell surface expression but also protects the FCGR3A protein from degradation ![](pubmed.jpg) |