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FLASH GENE
Symbol FCGR3A contributors: mct/npt - updated : 04-09-2017
HGNC name Fc fragment of IgG, low affinity IIIa, receptor for (CD16)
HGNC id 3619
Corresponding disease
IMD20 Immunodeficiency 20
Location 1q23.3      Physical location : 161.511.552 - 161.520.413
Synonym name
  • cell differentiation antigen CD16,50-65kD, low affinity Fc gamma RIII receptor, glycosyl-phosphatidylinositol (GPI) linked membrane glycoprotein, identified by monoclonal antibodies BW209/2, 3G8, CLB/FcGran1, B73.1 (see IGFCR@)
  • immunoglobulin G Fc receptor III
  • neutrophil-specific antigen NA
  • Synonym symbol(s) CD16, FCG3, FCGR3, IGFR3, FC3A, FCR-10, FCRIII, FCRIIIA, IGFR3, CD16a
    DNA
    TYPE functioning gene
    STRUCTURE 8.86 kb     5 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    alternative promoter
    Binding site   transcription factor
    motif repetitive sequence   other
    text structure
  • three alternative promoter, Pmed1/2 and Pprox in the 5'UTR (Pmed1 containing binding sites for Sp1 and NK element-recognizing factor)
  • only FCGR3A, FCGR2C and FCGR3B show CNV
  • MAPPING cloned Y linked   status confirmed
    Physical map
    NIT1 1q21-q22 nitrilase 1 DEDD 1q21.3 death effector domain containing HSPC155 1q23.1 hypothetical protein HSPC155 USP21 1q22 ubiquitin specific protease 21 PPOX 1q22 protoporphyrinogen oxidase B4GALT3 1q21-q23 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 ADAMTS4 1q23 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4 NDUFS2 1q23 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) FCER1G 1q23 Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide APOA2 1q21-q23 apolipoprotein A-II FLJ12770 1q23.1 hypothetical protein FLJ12770 NR1I3 1q23.1 nuclear receptor subfamily 1, group I, member 3 MPZ 1q22 myelin protein zero (Charcot-Marie-Tooth neuropathy 1B) SDHC 1q21 succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa LOC257177 1q23.1 similar to hypothetical protein MGC20470 LOC148430 1q23.1 similar to ribosomal protein S2; 40S ribosomal protein S2 LOC388709 1 LOC388709 LOC388710 1 LOC388710 FCGR2A 1q23 Fc fragment of IgG, low affinity IIa, receptor for (CD32) HSPA6 1q heat shock 70kDa protein 6 (HSP70B') FCGR3A 1q23 Fc fragment of IgG, low affinity IIIa, receptor for (CD16) FCGR3B 1q23 Fc fragment of IgG, low affinity IIIb, receptor for (CD16) FCGR2B 1q23 Fc fragment of IgG, low affinity IIb, receptor for (CD32) FREB 1q23.1 Fc fragment of IgG, low affinity IIb, receptor for (CD32) FLJ31052 1q23.1 hypothetical protein FLJ31052 DUSP12 1q22 dual specificity phosphatase 12 ATF6 1q22-q23 activating transcription factor 6
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2406 - 290 - 1990 2139735
    5 - 2338 - 289 - 1990 2139735
    6 - 2204 - 254 - 1990 2139735
    6 - 2186 - 254 - 1990 2139735
    6 - 2183 - 253 - 1990 2139735
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   predominantly
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Lymphoid/Immunemacrophage
    Lymphoid/Immunenatural killer Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal sequence, two Ig-like extracellular domain
  • a single transmembrane (TM) domain (TM1)
  • a protein kinase C (PKC) phosphorylation consensus motif [RSSTR], pecifically phosphorylated by PKCs
  • a short cytoplasmic tail whose expression at the cell surface depends on association with the signaling adaptor molecules CD247 and/or FCER1G
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY immunity/defense , antigen , receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • mediating antibody-dependent cellular cytotoxicity and other antibody-dependent responses, such as phagocytosis
  • plays a prominent role in the elimination of tumor cells by antibody-based cancer therapies
  • is involved in the pathogenesis of coronary heart disease (CHD) by activating monocytes and stimulating inflammation
  • role for FCGR3B in the removal of soluble immune complexes within the vasculature that may serve to maintain homeostasis
  • FCGR3A and PRF1 may participate in the pathogenesis and progression of primary biliary cirrhosis (PBC)
  • shedding of FCGR3A/CD16A was at least partially ADAM17 dependent, and it may be considered as a marker of FCGR3A/CD16A-independent NK cell activation highly correlated with degranulation
  • FCGR3A, FCGR3B are IgG Fc receptors expressed by human natural killer (NK) cells and neutrophils, respectively
  • association of the adaptor modules FCER1G or CD247 with FCGR3A not only is required for progression of this receptor through the secretory pathway and cell surface expression but also protects the FCGR3A protein from degradation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • over-activation of ADAM17 in NK cells may be detrimental to their effector functions by down-regulating surface expression of FCGR3A and SELL
  • MMP25 is a proteinase responsible for FCGR3A downmodulation
  • FCGR3A cleavage by ADAM17, but non-cleavable version of FCGR3A can be expressed in engineered NK cells (
  • expression of the FCGR3A depends on a noncovalent association with the signaling dimers FCER1G and/or CD247
  • FCGR3A requires association with adaptor modules for cell surface expression but shows no preference for assembly with either CD247 or FCER1G
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) IMD20
    Susceptibility
  • to systemic lupus erythematosus (SLE)
  • to viral infections, recurrent and neutropenia, alloimmune neonatal
  • to Takayasu arteritis
  • to HIV infection and progression
  • to immune thrombocytopenia (ITP)
  • Variant & Polymorphism other
  • genetic association between Takayasu arteritis and the FCGR2A/FCGR3A locus
  • homozygous for the high activity allele of FCGR3A (158VV) were predominantly found among HIV progressors and this group was also skewed toward higher allele frequencies for the V158 variant
  • FCGR3A (158V/F) polymorphism, known to increase the affinity of FCGR3A to IgG, was over-represented in ITP patients
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS