Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
|  
| gain of function
|
in gastric cancer (may be associated with alternative splicing) | tumoral
|  
|  
|  
| loss of function
|
by aberrant methylation of promoter of exon 1 in neuroblastoma | tumoral
|  
|  
|  
| gain of function
|
in breast cancer | tumoral
|  
|  
|  
| loss of function
|
in breast cancer, amplified in gastric cancer (maybe associated with alternative splicing) | tumoral
|  
|  
|  
| loss of function
|
in prostate carcinoma (primary or with metastases) | tumoral
|  
|  
| --over
|  
|
of CD44v6, especially in early-onset gastric carcinomas | tumoral
|  
|  
| --over
|  
|
may be an independent unfavorable prognostic factor for overall survival in advanced CRC, especially stage IV disease ![](pubmed.jpg) | constitutional
|  
|  
| --over
|  
|
higher levels of CD34, CD44, and LIF were found in the placentas of pre-eclamptic compared with normotensive women ![](pubmed.jpg) | |
| any obvious developmental or neurological deficits in mice in which expression of all known isoforms of CD44 is abolished ![](pubmed.jpg) | |
CD44-deficient fibroblasts were highly tumorigenic in nude mice ![](pubmed.jpg) |
|
In CD44(-/-) mice, postpartum uterine involution is accelerated and maintenance of lactation is impaired ![](pubmed.jpg) |
|
CD44-deficient mice succumb to unremitting inflammation following noninfectious lung injury ![](pubmed.jpg) |
|
Macrophage recruitment into M. tuberculosis-infected lungs and delayed-type hypersensitivity sites is impaired in CD44-deficient CD44-/- mice. CD44-/- mice displayed a decreased survival and an enhanced mycobacterial outgrowth in lungs and liver during pulmonary tuberculosis ![](pubmed.jpg) |
|
CD44(-/-) human TNF-transgenic mice display severe generalized osteopenia and an increased bone resorption due to enhanced number, size, and resorptive capacity of osteoclasts ![](pubmed.jpg) |