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FLASH GENE

Symbol

CD44

contributors: shn/pgu - updated : 22-04-2016

HGNC name	CD44 molecule (Indian blood group)
HGNC id	1681

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       gain of function in gastric cancer (may be associated with alternative splicing) tumoral       loss of function by aberrant methylation of promoter of exon 1 in neuroblastoma tumoral       gain of function in breast cancer tumoral       loss of function in breast cancer, amplified in gastric cancer (maybe associated with alternative splicing) tumoral       loss of function in prostate carcinoma (primary or with metastases) tumoral     --over   of CD44v6, especially in early-onset gastric carcinomas tumoral     --over   may be an independent unfavorable prognostic factor for overall survival in advanced CRC, especially stage IV disease constitutional     --over   higher levels of CD34, CD44, and LIF were found in the placentas of pre-eclamptic compared with normotensive women

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurosensorial     inhibition of HA-CD44 interaction leads to significant suppression of inflammation-related choroidal neovascularization (CNV) indicating the possibility of HA-CD44 blockage as a therapeutic target for inhibiting CNV in age macular dystrophy cancer lung   targeting CD44 could be an effective strategy for halting Kras-dependent carcinomas

ANIMAL & CELL MODELS

	any obvious developmental or neurological deficits in mice in which expression of all known isoforms of CD44 is abolished
	CD44-deficient fibroblasts were highly tumorigenic in nude mice
	In CD44(-/-) mice, postpartum uterine involution is accelerated and maintenance of lactation is impaired
	CD44-deficient mice succumb to unremitting inflammation following noninfectious lung injury
	Macrophage recruitment into M. tuberculosis-infected lungs and delayed-type hypersensitivity sites is impaired in CD44-deficient CD44-/- mice. CD44-/- mice displayed a decreased survival and an enhanced mycobacterial outgrowth in lungs and liver during pulmonary tuberculosis
	CD44(-/-) human TNF-transgenic mice display severe generalized osteopenia and an increased bone resorption due to enhanced number, size, and resorptive capacity of osteoclasts