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	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

GATA3

contributors: mct/pgu - updated : 03-02-2016

HGNC name	GATA binding protein 3
HGNC id	4172

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

HDR

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   aberrant expression in pancreatic cancer tumoral     --over   in ESR1-positive breast tumors tumoral     --over   during the late secretory phase in the endometrium, suggesting antagonistic function and/or regulation between progesterone receptor and TBX21/GATA3

Susceptibility

to Hodgkin lymphoma

Variant & Polymorphism SNP	SNP increasing the risk of Hodgkin lymphoma

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed miscelleaneous vascular   therapies designed to maintain GATA3 activity might help to blunt the deleterious effects of inflammation on the endothelium

ANIMAL & CELL MODELS

GATA3 leads to embryonic lethality due to noradrenaline deficiency of the sympathic nervous system,in mice