basic FUNCTION
| an essential mediator of p53 in the transcriptional induction of p21(WAF1/Cip1) |
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inhibitor of the cell cycle, acting both as a transcriptional activator and repressor |
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required for terminal differentiation of gobelet cells in the colon |
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essential for terminal differentiation of the epidermis and intestinal epithelium |
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a novel regulator of u-PAR expression that drives the synthesis of u-PAR in the luminal surface epithelial cells of the colon |
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may be a key effector of PDGFB and injury-induced phenotypic switching of smooth muscle cells |
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cooperating with POU5F1 and SOX2 to activate LEFTY1 expression and acting as a mediating factor that specifically binds to the proximal element of the LEFTY1 promoter |
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may be playing a role during spermiogenesis (altered subcellular localization of the protein during arrested spermiogenesis) |
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critical regulator in the transcriptional network controlling monocyte differentiation |
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can induce, in cooperation with Oct3/4, Sox2, and c-Myc, a variety of somatic cells into an embryonic stem cell-like state or induced pluripotent stem cells |
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involved in phenotypic modulation of vascular smooth muscle cells (VSMCS), and required for the expression of VSMC differentiation marker genes induced by all-trans retinoic acid |
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regulates both differentiation and growth that is likely fundamental to its tumor suppressor activity |
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playing an important role as a regulator of key signaling pathways that control macrophage activation |
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playing an important role in regulating the expression of IL10 |
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epithelial cell-enriched, zinc finger-containing, transcription factor that has been widely investigated in both normal development and carcinogenesis |
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being a critical regulator in the transcriptional network controlling monocyte differentiation |
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suppresses tumorigenesis in gastrointestinal epithelium |
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pleiotropic zinc finger transcription factor that regulates genes being involved in differentiation and cell-cycle control |
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positively regulates human ghrelin expression via binding to a KLF-responsive region in the promoter |
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required for normal gastric epithelial proliferation and differentiation |
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possess both tumor suppressive and oncogenic functions in breast cancers |
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involved in mediating LIF signalling to the core circuitry but are not directly associated with the maintenance of pluripotency |
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implicated in vascular smooth muscle cell differentiation induced by all-trans retinoic acid (ATRA) |
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suppresses estrogen-dependent breast cancer growth by inhibiting the transcriptional activity of ESR1 |
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transcriptional repressor of axon growth in retinal ganglion cells and other central nervous system neurons and regulates the regenerative capacity of central nervous system neurons |
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preventing ES cell differentiation by regulating NANOG gene expression |
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inhibits epithelial-to-mesenchymal transition in mammary epithelial cells through regulation of CDH1 gene expression and thus may have a metastasis suppressive role in breast cancer |
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plays a key role in late fetal and/or postnatal cardiac development |
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key role of KLF4 in the regulation of CDH5 expression at the level of the adherens junctions and in the acquisition of CDH5-mediated endothelial barrier function) |
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plays a key role in the maturation of TRH expression in hypothalamic neurons |
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transcription factor that plays an important role in cell differentiation, proliferation, and survival, especially in the context of cancers |
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plays a role in maintenance of high glycolytic metabolism by transcriptional activation of the PFKP gene in breast cancer cells |
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contributes to the stimulation of glycolytic metabolism in breast cancer cells by activating PFKP transcription |
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critical role of KLF4 in endothelial physiology |
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contributes potentially to high phosphate-induced conversion of SMCs into osteogenic cells |
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high phosphate-induced phenotypic switching of SMCs is mediated in part by KLF4 |
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regulated the transcription of osteogenic genes in SMCs |
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having likely dual roles during the vascular calcification process: not only decreasing expression of SMC differentiation marker genes, but also inducing osteogenic genes |
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KLF4 is expressed in neural stem cells and controls axonal regeneration |
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precise regulation of KLF4 expression is critical to neuronal differentiation and migration during the formation of a cerebral cortex |
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is a zinc finger-containing transcription factor that regulates multiple biological functions, including proliferation and differentiation |
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KLF4 has a direct role in governing the morphological change of migrating neurons |
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balance between ZEB2 and KLF4 protein levels is important for the modulation of CDH1 expression |
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may serve as an essential regulator of endothelial barrier function |
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.ADORA2B is a regulator of adipocyte differentiation and the ADORA2B-KLF4 axis is a potentially significant modulator of adipose biology |
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KLF4 is a critical regulator of monocyte differentiation and macrophage polarization, and it also plays an important role in several vascular diseases, including atherosclerosis |
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novel function for KLF4 in regulating the MAP2K7 pathway in T-ALL cells, which can be targeted to eradicate leukemia-initiating cells in T-ALL patients |
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novel function of DDX3X in regulating expression and downstream functions of KLF4, a master negative regulator of the cell cycle |
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