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FLASH GENE
Symbol FOXH1 contributors: mct - updated : 03-10-2006
HGNC name forkhead box H1
HGNC id 3814
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a forkhead (FH, winged helix) domain with two loops-wings on the C-terminal side of helix-turn-helix homeo domain
    • HOMOLOGY
    interspecies homolog to Xenopus forkhead activin signal transducer-1
    Homologene
    FAMILY HNF-3 FKH family of transcriptional activators
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • embryonic transcriptional regulator
  • TGF-beta/activin signal transducer
  • regulating NODAL and LEFTB
  • activating the activin response element (ARE) after SMAD4 binding and TGF beta stimulation
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text left/right asymetry
    PATHWAY
    metabolism
    signaling signal transduction
    a component complexing with SMAD2, SMAD4
    INTERACTION
    DNA binding to ASE (asymetric enhancers) of NODAL and LEFTB
    RNA
    small molecule
    protein
  • binding to SMAD2
  • physically interacts with SESN1
    • cell & other
    REGULATION
    activated by NODAL through activin receptors ACVR1B,ACVR2,ACVR2B
    ASSOCIATED DISORDERS
    corresponding disease(s) HPE16
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    expressed on both sides of the LPM