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FLASH GENE
Symbol FOXH1 contributors: mct - updated : 03-10-2006
HGNC name forkhead box H1
HGNC id 3814
Corresponding disease
HPE16 holoprosencephaly 16
Location 8q24.3      Physical location : 145.699.116 - 145.701.718
Synonym name forkhead activin signal transducer 1
Synonym symbol(s) FAST1
DNA
TYPE functioning gene
STRUCTURE 2.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovary   
 male systemtestis   
cell lineage
cell lines several cancer cell lines (ARE)
fluid/secretion
at STAGE
physiological period embryo
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a forkhead (FH, winged helix) domain with two loops-wings on the C-terminal side of helix-turn-helix homeo domain
    • HOMOLOGY
    interspecies homolog to Xenopus forkhead activin signal transducer-1
    Homologene
    FAMILY HNF-3 FKH family of transcriptional activators
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • embryonic transcriptional regulator
  • TGF-beta/activin signal transducer
  • regulating NODAL and LEFTB
  • activating the activin response element (ARE) after SMAD4 binding and TGF beta stimulation
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text left/right asymetry
    PATHWAY
    metabolism
    signaling signal transduction
    a component complexing with SMAD2, SMAD4
    INTERACTION
    DNA binding to ASE (asymetric enhancers) of NODAL and LEFTB
    RNA
    small molecule
    protein
  • binding to SMAD2
  • physically interacts with SESN1
    • cell & other
    REGULATION
    activated by NODAL through activin receptors ACVR1B,ACVR2,ACVR2B
    ASSOCIATED DISORDERS
    corresponding disease(s) HPE16
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    expressed on both sides of the LPM