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FLASH GENE
Symbol TIMM13 contributors: /mct - updated : 03-02-2003
HGNC name translocase of inner mitochondrial membrane 13 homolog (yeast)
HGNC id 11816
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a largely alpha-helical structure,one on the N terminal region terminated by two cysteine residues,one central comprising two cysteine residues
  • a third one and separated from each other by random coil and suggesting a hairpin of helices held together by the cysteine coodination of the Zn2 + ion
    • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae translocase of inner mitochondrial membrane 13,B (Tim13p)
    Homologene
    FAMILY
  • small Tim family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • involved in the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling sensory transduction/hearing
    a component
  • component of the Tm complex
  • complexing with TIMM8A in the mitochondrial intermembrane space
  • TIM22 protein import pathway consists of two intermembrane space chaperone complexes, the TIMM9-TIMM10 and TIMM8A-TIMM13 complexes (Hasson 2010)
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • interactig with SLC25A12 and SLC25A13
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS