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FLASH GENE

Symbol

TIMM13

contributors: /mct - updated : 03-02-2003

HGNC name	translocase of inner mitochondrial membrane 13 homolog (yeast)
HGNC id	11816

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem
text	in a head-to-tail orientation with the gene for lamin B2
STRUCTURE	2.25 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	pter - TIMM13 - D19S413 - cen
Authors	Jin (99)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_012458 3 - 1977 NP_036590 10.4 95 - -

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive liver         Endocrine pancreas       highly Nervous brain       highly Reproductive male system prostate     highly Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Nervous Purkinje cell

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text

weakly

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a largely alpha-helical structure,one on the N terminal region terminated by two cysteine residues,one central comprising two cysteine residues
	a third one and separated from each other by random coil and suggesting a hairpin of helices held together by the cysteine coodination of the Zn2 + ion

HOMOLOGY

interspecies

homolog to yeast S.cerevisiae translocase of inner mitochondrial membrane 13,B (Tim13p)

Homologene

FAMILY

small Tim family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,membrane

basic FUNCTION

involved in the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

sensory transduction/hearing

a component	component of the Tm complex
	complexing with TIMM8A in the mitochondrial intermembrane space
	TIM22 protein import pathway consists of two intermembrane space chaperone complexes, the TIMM9-TIMM10 and TIMM8A-TIMM13 complexes (Hasson 2010)

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein

interactig with SLC25A12 and SLC25A13

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS