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FLASH GENE
Symbol EDIL3 contributors: mct/npt - updated : 11-04-1201
HGNC name EGF-like repeats and discoidin I-like domains 3
HGNC id 3173
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three epidermal growth factor repeats (E1-E3) at its N-terminus
  • a RGD motif
  • two discoidin domains (C1, C2) at its C-terminus, contributing to its deposition in the extracellular matrix (Hidai 2007)
  • a Del1 deposition domain (DDD), that could immobilize an enzyme in the ECM without interfering with function (Hidai 2009)
    • HOMOLOGY
    interspecies homolog to murine Del1
    Homologene
    FAMILY
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
    text
  • in the extracellular matrix (Hidai 2007)
  • organized in the extracellular matrix (ECM) via the Del1 deposition domain (DDD) (Hidai 2009)
    • basic FUNCTION
  • promoting the adhesion of endothelial cells through interaction with the AVB3 integrin receptor
  • putative regulator of vascular morphogenesis or remodeling in embryonic development
  • mediates cell attachment, migration, and activation of cytoplasmic signaling molecules in focal contacts (Aoka 2002)
  • acts as an angiogenic factor in the context of solid tumor formation and this increase in vascularization accelerates tumor growth through decreased apoptosis (Aoka 2002)
  • endogenous inhibitor of inflammatory cell recruitment that could provide a basis for targeting leukocyte-endothelial interactions in disease (Choi 2008)
  • may induce apoptosis via its epidermal growth factor motif (Kitano 2010)
  • EDIL3, AMOT and ECM1 are involved in the excessive angiogenesis and vasodilation observed in psoriasis
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • unique alpha V beta 3 integrin ligand that is produced by endothelial cells, and thus provides an autocrine signaling pathway in this cell type (Aoka 2002), and play an important role in the process of tumor cells moving from the original place (Niu 2007)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   amplification    
    recurring copy-number variants in congenital heart disease
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS