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FLASH GENE
Symbol BASP1 contributors: mct/npt/pgu - updated : 21-03-2013
HGNC name brain abundant, membrane attached signal protein 1
HGNC id 957
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • basic N-terminal domain containing a myristoylation site
  • three potential phosphorylation sites
  • a calmodulin binding domain
  • a putative nuclear localization signal is essential for the inhibitory function of BASP1
  • several C terminal PEST sequences.
    • HOMOLOGY
    interspecies homolog to rattus Nap22,chicken Cap23
    Homologene
    FAMILY
  • BASP/NAP22 family
    • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text in axon terminals and dendritic spines
    basic FUNCTION
  • involved in the maturation and/or the maintenance of synapse rather than in the process of the axonal outgrowth by controlling cholesterol-dependent membrane dynamics
  • signal protein participating in neurite outgrowth and synaptic plasticity
  • play a role in DNA repair and cell cycle regulation
  • BASP1 and GAP43 have overlapping, but not identical, functions in relation to neurite outgrowth and the main function of BASP1 is to regulate the organization and morphology of the plasma membrane
  • transcriptional cosuppressor that can block the transcriptional activation function of WT1
  • dynamic cooperation between WT1 and BASP1 in the regulation of gene expression during differentiation
  • nuclear factor regulating the transcriptional activity of the Wilms' tumor suppressor protein WT1
  • potential tumor suppressor
  • GAP43 and BASP1 participate in the regulation of actin cytoskeleton dynamics in neuronal axon terminals
  • WT1 and BASP1 can divert the lineage potential of an established blood cell line towards a cell with neuronal characteristics
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • Ca2+
    • protein
  • binding to FMR1 (RNA target of FMR1)
  • binding to calmodulin in a calcium dependent manner
  • target suppressed by MYC (specifically suppressed in fibroblasts transformed by the v-myc oncogene, but not in cells transformed by other oncogenic agents)
  • is a WT1 cofactor that suppresses the transcriptional activation function of WT1
  • BASP1 interacts with WT1 and converts WT1 from a transcriptional activator to a repressor
  • BASP1 myristoylation and association with INPP5J are required for the interaction of BASP1 with HDAC1, which mediates the recruitment of HDAC1 to the promoter and elicits transcriptional repression
  • could participate in the transport of GAD2 and GAD1 to the presynaptic termini and their retention on the synaptic vesicles as an anchoring protein
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    stimulated neurite outgrowth in primary hippocampal neurons
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS