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FLASH GENE

Symbol

BASP1

contributors: mct/npt/pgu - updated : 21-03-2013

HGNC name	brain abundant, membrane attached signal protein 1
HGNC id	957

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node           spleen         Nervous brain       highly Homo sapiens Reproductive male system testis       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid         Nervous central       Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	developing nephron structures of the embryonic kidney, particularly abundant in neurons during brain development and implicated in neurite outgrowth

PROTEIN

PHYSICAL PROPERTIES		acid
STRUCTURE

motifs/domains	basic N-terminal domain containing a myristoylation site
	three potential phosphorylation sites
	a calmodulin binding domain
	a putative nuclear localization signal is essential for the inhibitory function of BASP1
	several C terminal PEST sequences.

HOMOLOGY

interspecies

homolog to rattus Nap22,chicken Cap23

Homologene

FAMILY

BASP/NAP22 family

CATEGORY

signaling

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytoskeleton
	intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
text	in axon terminals and dendritic spines

basic FUNCTION	involved in the maturation and/or the maintenance of synapse rather than in the process of the axonal outgrowth by controlling cholesterol-dependent membrane dynamics
	signal protein participating in neurite outgrowth and synaptic plasticity
	play a role in DNA repair and cell cycle regulation
	BASP1 and GAP43 have overlapping, but not identical, functions in relation to neurite outgrowth and the main function of BASP1 is to regulate the organization and morphology of the plasma membrane
	transcriptional cosuppressor that can block the transcriptional activation function of WT1
	dynamic cooperation between WT1 and BASP1 in the regulation of gene expression during differentiation
	nuclear factor regulating the transcriptional activity of the Wilms' tumor suppressor protein WT1
	potential tumor suppressor
	GAP43 and BASP1 participate in the regulation of actin cytoskeleton dynamics in neuronal axon terminals
	WT1 and BASP1 can divert the lineage potential of an established blood cell line towards a cell with neuronal characteristics

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding, cofactor,
	Ca2+

protein	binding to FMR1 (RNA target of FMR1)
	binding to calmodulin in a calcium dependent manner
	target suppressed by MYC (specifically suppressed in fibroblasts transformed by the v-myc oncogene, but not in cells transformed by other oncogenic agents)
	is a WT1 cofactor that suppresses the transcriptional activation function of WT1
	BASP1 interacts with WT1 and converts WT1 from a transcriptional activator to a repressor
	BASP1 myristoylation and association with INPP5J are required for the interaction of BASP1 with HDAC1, which mediates the recruitment of HDAC1 to the promoter and elicits transcriptional repression
	could participate in the transport of GAD2 and GAD1 to the presynaptic termini and their retention on the synaptic vesicles as an anchoring protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   stimulated neurite outgrowth in primary hippocampal neurons

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS