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FLASH GENE
Symbol BASP1 contributors: mct/npt/pgu - updated : 21-03-2013
HGNC name brain abundant, membrane attached signal protein 1
HGNC id 957
DNA
TYPE functioning gene
STRUCTURE 59.19 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure
  • 2 exons separated by a 58-kbp intron and a Myc-responsive regulatory region at the 5 prime boundary of untranslated exon 1
  • promoter was specifically down-regulated in v-myc-transformed cells
  • regulation of BASP1 promoter occupancy involves the sumoylation of BASP1
    • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1820 25 227 - 2000 10965107
    - - 1727 - 227 - 2000 10965107
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    
     spleen    
    Nervousbrain   highly Homo sapiens
    Reproductivemale systemtestis   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    Nervouscentral   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text developing nephron structures of the embryonic kidney, particularly abundant in neurons during brain development and implicated in neurite outgrowth
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • basic N-terminal domain containing a myristoylation site
  • three potential phosphorylation sites
  • a calmodulin binding domain
  • a putative nuclear localization signal is essential for the inhibitory function of BASP1
  • several C terminal PEST sequences.
    • HOMOLOGY
    interspecies homolog to rattus Nap22,chicken Cap23
    Homologene
    FAMILY
  • BASP/NAP22 family
    • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text in axon terminals and dendritic spines
    basic FUNCTION
  • involved in the maturation and/or the maintenance of synapse rather than in the process of the axonal outgrowth by controlling cholesterol-dependent membrane dynamics
  • signal protein participating in neurite outgrowth and synaptic plasticity
  • play a role in DNA repair and cell cycle regulation
  • BASP1 and GAP43 have overlapping, but not identical, functions in relation to neurite outgrowth and the main function of BASP1 is to regulate the organization and morphology of the plasma membrane
  • transcriptional cosuppressor that can block the transcriptional activation function of WT1
  • dynamic cooperation between WT1 and BASP1 in the regulation of gene expression during differentiation
  • nuclear factor regulating the transcriptional activity of the Wilms' tumor suppressor protein WT1
  • potential tumor suppressor
  • GAP43 and BASP1 participate in the regulation of actin cytoskeleton dynamics in neuronal axon terminals
  • WT1 and BASP1 can divert the lineage potential of an established blood cell line towards a cell with neuronal characteristics
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • Ca2+
    • protein
  • binding to FMR1 (RNA target of FMR1)
  • binding to calmodulin in a calcium dependent manner
  • target suppressed by MYC (specifically suppressed in fibroblasts transformed by the v-myc oncogene, but not in cells transformed by other oncogenic agents)
  • is a WT1 cofactor that suppresses the transcriptional activation function of WT1
  • BASP1 interacts with WT1 and converts WT1 from a transcriptional activator to a repressor
  • BASP1 myristoylation and association with INPP5J are required for the interaction of BASP1 with HDAC1, which mediates the recruitment of HDAC1 to the promoter and elicits transcriptional repression
  • could participate in the transport of GAD2 and GAD1 to the presynaptic termini and their retention on the synaptic vesicles as an anchoring protein
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    stimulated neurite outgrowth in primary hippocampal neurons
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS