basic FUNCTION
| playing an important role in coupling antigen recognition to several intracellular signal-transduction pathways |
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playing a role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering |
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playing a necessary role for the development and function of T cells, and participating in intrathymic T-cell differentiation |
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functions as an amplification module in the TCR signaling cascade and is essential for assembly and surface expression of the TCR/CD3 complex |
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the stalks of the CD3G, CD3E, CD3D, CD247 may be critical in transmitting part of the activation signal directly through the membrane |
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modulates blood pressure by altering T-lymphocyte infiltration in the kidney |
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CD247 and FCER1G are integral membrane proteins that have subsequently been found to be obligate signaling adaptors for many immunoreceptors in different cell types |
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association of the adaptor modules FCER1G or CD247 with FCGR3A not only is required for progression of this receptor through the secretory pathway and cell surface expression but also protects the FCGR3A protein from degradation |
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LAT, like CD247 and ZAP70, plays likely a role in neurogenesis and that perturbation of this pathway may lead to neurodevelopmental phenotypes |