SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,cytosolic,granule
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| intracellular,cytoplasm,cytoskeleton,microtubule
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text
| located mainly in the dendrites of cerebellar granule neurons, in contrast to the axonal distribution in hippocampal neurons |
basic FUNCTION
| plays a role in axon guidance, neuronal growth cone collapse and cell migration |
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plays a critical role in the establishment of neuronal polarity |
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involved in the developmental process of the nervous system, oligodendroglia process extension |
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playing a critical role in axon outgrowth and axon-dendrite specification |
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critical for specifying axon/dendrite fate and axon growth in cultured hippocampal neurons |
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balance between cytoplasmic full-length CRMP2 and post-transcriptionally processed forms of CRMP2 translocated to the nuclear compartment may represent an important key in the regulation of neurite outgrowth during normal brain development |
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transports the Sra-1/WASF1 complex to axons in a kinesin-1-dependent manner and thereby regulates axon outgrowth and formation |
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involved in pathways that regulate the proliferation of non-neuronal cells through its phosphorylation by regulatory proteins |
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playing a role in signaling pathways that regulate the proliferation of non-neuronal cells |
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play a crucial role in neuronal differentiation and axonal outgrowth, and mediates axonal guidance by collapsing growth cones during development |
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may act as a regulator of other functions, such as migration and proliferation |
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complex of KLC1, KIF5C and CRMP2 is involved in transporting tubulin heterodimers and oligomers to the tip of the growing axon |
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promotes the assembly of tubulin subunits onto the ends of existing microtubules and is required for axon formation |
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binds to tubulin heterodimers to promote microtubule assembly |
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essential for axon-dendrite specification, axon outgrowth, and elongation |
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can regulate microtubule assembly, reorganization of actin filaments, and protein trafficking during neurite elongation and axon specification |
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may be required for multipolar to bipolar transition for directional neuronal migration and neurite outgrowth |
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plays essential roles at multiple stages of neuronal development |
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INPP5J and DPYSL2 exert opposing roles in promoting axon selection and neurite elongation and the complex between these proteins serves to regulate the localization of effectors that promote neurite extension |
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modulates Ca2+ channel activity via alterations in surface expression |
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not only involved in glutamate-mediated neurotoxicity but may be effectively targeted to prevent excitotoxicity-mediated neuronal death |
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plays a pivotal role in promoting axon formation, neurite outgrowth and elongation in neuronal cells |
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is a protein critically involved in primary cilia formation |
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ARPC5 and DPYSL2 are closely associated with neurite outgrowth in brain development |
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novel role for SUMO modification in DPYSL2/CACNA1B signaling pathway |
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tethers kainate receptor activity to cytoskeleton dynamics during neuronal maturation |
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is traditionally viewed as an axonal growth protein involved in axon/dendrite specification |
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DPYSL2 and DPYSL3 interacted with one another coordinately to promote growth cone development and axonal elongation |
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DPYSL2 and DPYSL3 form likely complexes to bridge microtubules and actin and thus work cooperatively to regulate growth cone development and axonal elongation |
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plays a key role in axon guidance, dendritic morphogenesis and cell polarization, and is implicated in various neurological and psychiatric disorders |