| Symbol
| ALOX15
| contributors: mct/npt - updated : 07-02-2023
|
| HGNC name
| arachidonate 15-lipoxygenase
|
| HGNC id
| 433
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --over
|
| |
in prostatic adenocarcinoma | | constitutional
|
|
| --over
|
|
in heart failure  | | tumoral
|
|
| --other
|
| |
expressed in primary Hodgkin Reed-Sternberg cells in classical Hodgkin lymphoma | | tumoral
|
|
|
| loss of function
| |
in colorectal cancer (CRC) | |
| Susceptibility
|
to coronary artery disease (CAD) to bone loss, fracture incidence to nasal polyps and chronic rhinosinusitis |
| Variant & Polymorphism
SNP
, other
| rs7217186:T>C and rs2619112:G>A of ALOX15 are associated with increased risk of CAD |
|
variation in ALOX15 was associated with bone microarchitecture and density in young adult women, but appears to be less important in the elderly |
|
a loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis |
| 
|
Candidate gene
Marker
Therapy target
|
|
| System | Type | Disorder | Pubmed |
|---|
| cardiovascular | aquired | | |
| inhibition of ALOX12/ALOX15 could be a novel treatment for heart failure | | immunology | infectious | | |
| ALOX15 pathway is a novel therapeutic target for the treatment of virus-associated asthma characterized by Th1 inflammation |
| | | |
|
| Cardiac fibrosis increased in Alox15 transgenic mice with advancing age and was associated with the infiltration of macrophages | |
Mice lacking Alox15 in & |
|
946; cells exhibit an increase in a population of beta cells expressing the gene encoding the protein programmed death ligand 1 (PD-L1), which engages receptors on immune cells to sssuppress autoimmunity |