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FLASH GENE
Symbol FILIP1 contributors: mct - updated : 18-01-2016
HGNC name filamin A interacting protein 1
HGNC id 21015
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • FILIP1 family
    • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • functioning through an FLNA-F-actin axis to initiate neocortical cell migration from the ventricular zone
  • acts through a Filamin A-F-actin axis to control the start of neocortical cell migration from the ventricular zone
  • is responsible, at least in part, for the Filamin A content of migrating neurons
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FILIP1 interacts with Filamin A, an indispensable actin-binding protein for cell motility, and induces its degradation
  • MKRN1 is involved in carcinogenesis of the well-differentiated type of tumors possibly via ubiquitination of FILIP1
  • RHOD binds WHAMM, as well as the related filamin A-binding protein FILIP1
  • subcellular localization and function of MYH10 are regulated by its binding partner, filamin-A interacting protein (FILIP1)
  • inhibition of ATPase activity of HSPA8 impaired the effect of FILIP1 on the subcellular distribution of MYH10
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS