| basic FUNCTION
| having DNA-binding activity, may be a DNA helicase |
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important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression |
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has roles in transcription, DNA repair and replication |
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playing a direct role in fork elongation, and being an important new player in DNA replication to help safeguard the integrity of the genome |
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has a crucial role in stabilizing a stalled replisome to ensure proper restart of DNA replication |
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has roles in transcriptional regulation, DNA double-strand break (DSB) repair and regulation of the DNA-damage cell-cycle checkpoint response |
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requiered by YY1 to YY1-activated genes, where it functions as an essential coactivator  |
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remodeling enzyme recruited to replication origins as cells enter S phase |
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its chromatin-remodeling activity regulates efficient progression of replication forks and has a crucial role in stabilizing a stalled replisome to ensure proper restart of DNA replication |
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required for efficient S-phase progression |
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proteasome with the INO80 chromatin-remodeling complex may cooperate to regulate transcription or DNA repair, processes in which both complexes have been implicated |
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assists DSB (double-strand break) repair by positively regulating the expression of the RAD54B and XRCC3 genes |
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can contribute to DSB repair indirectly via gene expression, suggesting that the mechanistic role of this chromatin remodeller in DSB repair is evolutionarily diversified |
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crucial role of the INO80 complex in DNA damage response |
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critical role in creating DNA accessibility for the nucleotide excision repair (NER) pathway and suggesting that repair of UV lesions and perhaps most bulky adduct lesions requires chromatin reconfiguration |
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INO80 ATP-dependent chromatin remodeling complex is a nucleosome spacing factor |
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regulates the genome-wide distribution of H2AFZ and it promotes the eviction of H2AFZ from promoters during transcriptional induction |
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catalyzes the removal of unacetylated H2AFZ from chromatin as a mechanism to promote genome stability |
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capable of catalyzing both ATP-dependent nucleosome sliding and DNA-dependent ATPase |
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is required for efficient double-strand break repair, mediating 5prime-3prime resection of double-strand break ends |
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can play a direct role in the spindle assembly independent of its chromatin remodeling activity |
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INO80 chromatin remodeling complex functions in transcriptional regulation, DNA repair, and replication |
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role of monomeric actin in INO80 chromatin remodeling |
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plays important roles in transcriptional regulation and DNA replication and repair, and consists of several functional protein subunits, including the critical INO80 ATPase catalytic subunit |
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is structurally and mechanistically distinct from SWI/SNF-type remodelers, and instead of providing a nucleosome-binding pocket, INO80 forms a flexible clamp in histone variant exchange and nucleosome remodeling |
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has a distinct mechanism of interacting with the nucleosome by forming a flexible cradle that could partially embrace the nucleosome |
