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FLASH GENE
Symbol LRFN2 contributors: mct - updated : 28-02-2014
HGNC name leucine rich repeat and fibronectin type III domain containing 2
HGNC id 21226
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six extracellular leucine-rich repeats domain (LRR)
  • a fibronectin type III domain (Fn)
  • an Immunoglobulin-like domain (Ig-like) C2 type domain
  • a single transmembrane (TM) domain
  • a putative dileucine ER retention motif, which is not present in the other SALMs
  • C-terminal PDZ-binding domain (PDZ-BD), which associates with the PSD-95 family of protein, may influence cellular trafficking of SALMs to specific neuronal locations and mediating LRFN2 surface expression
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Lrfn2 (95,68 pc)
    homolog to murine Lrfn2 (95,30 pc)
    intraspecies homolog to neurogenic extracellular SLIT2 protein
    Homologene
    FAMILY
  • Synaptic adhesion-like molecules (SALMs) family
  • superfamily of leucine-rich repeat (LRR)-containing adhesion molecules
    • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    text in synaptic membrane and postsynaptic density fractions but also distributed in axons and dendrites
    basic FUNCTION
  • neuronal component with a role in the developing or mature vertebrate nervous system
  • transmembrane adhesion-type molecule, able to subvert hematopoietic differentiation to increase erythropoiesis
  • play critical roles in the formation and maintenance of the central nervous system
  • LRFN2 functions in neurite outgrowth while LRFN1 is involved in synapse formation
  • implicated in the regulation of neurite outgrowth and branching, and synapse formation and maturation
  • having a unique mechanism of trafficking through the ER
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component homomeric or heteromeric complexes in brain and heterologous cells
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PSD95 binding
  • interacts with synapse-associated protein 102 (SAP102), and SAP97
  • also interacts with the NMDA receptor NR1 subunit through its extracellular or TM1 domains
  • directly interacts with NMDA receptors but not with AMPA receptors
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS