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FLASH GENE

Symbol

LRFN2

contributors: mct - updated : 28-02-2014

HGNC name	leucine rich repeat and fibronectin type III domain containing 2
HGNC id	21226

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       specific Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	brain moderately

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	six extracellular leucine-rich repeats domain (LRR)
	a fibronectin type III domain (Fn)
	an Immunoglobulin-like domain (Ig-like) C2 type domain
	a single transmembrane (TM) domain
	a putative dileucine ER retention motif, which is not present in the other SALMs
	C-terminal PDZ-binding domain (PDZ-BD), which associates with the PSD-95 family of protein, may influence cellular trafficking of SALMs to specific neuronal locations and mediating LRFN2 surface expression

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to rattus Lrfn2 (95,68 pc)
	homolog to murine Lrfn2 (95,30 pc)

intraspecies

homolog to neurogenic extracellular SLIT2 protein

Homologene

FAMILY	Synaptic adhesion-like molecules (SALMs) family
	superfamily of leucine-rich repeat (LRR)-containing adhesion molecules

CATEGORY

adhesion

SUBCELLULAR LOCALIZATION	plasma membrane,junction
text	in synaptic membrane and postsynaptic density fractions but also distributed in axons and dendrites

basic FUNCTION	neuronal component with a role in the developing or mature vertebrate nervous system
	transmembrane adhesion-type molecule, able to subvert hematopoietic differentiation to increase erythropoiesis
	play critical roles in the formation and maintenance of the central nervous system
	LRFN2 functions in neurite outgrowth while LRFN1 is involved in synapse formation
	implicated in the regulation of neurite outgrowth and branching, and synapse formation and maturation
	having a unique mechanism of trafficking through the ER

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

homomeric or heteromeric complexes in brain and heterologous cells

INTERACTION

DNA

RNA

small molecule

protein	PSD95 binding
	interacts with synapse-associated protein 102 (SAP102), and SAP97
	also interacts with the NMDA receptor NR1 subunit through its extracellular or TM1 domains
	directly interacts with NMDA receptors but not with AMPA receptors

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS