basic FUNCTION
| involved in embryonic development, cell lineage gene regulation and cell cycle control |
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involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of |
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DNA-nucleosome topology) |
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may participate in globin regulation and may be important in the normal physiology of erythrocytes |
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implicated in the cross talk of histone modifications |
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plays an important role in early development |
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Trithorax g protein functioning as an E3 ubiquitin ligase adapter for histone H2BK120 and having important implications for chromatin remodeling by SWI/SNF and H2B monoubiquitination, an upstream event of H3K4 trimethylation associated with gene activation |
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DNA-binding subunit of the Brahma-associated factor chromatin remodelling complexes, which play a key role in the regulation of gene activity |
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is likely to play a key role in neurodevelopment and reduced levels of wild-type protein compromise normal brain development |
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repressor of WNT/CTNNB1 signaling |