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FLASH GENE
Symbol ADAMTSL3 contributors: mct - updated : 07-11-2009
HGNC name ADAMTS-like 3
HGNC id 14633
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • immunoglobulin and thrombospondin domain
  • one disintegrin-like domain
  • one plac domain
  • 13 thrombospondin type 1 repeats (TSRs), arranged in two arrays separated by a region containing three immunoglobulin-like repeats
  • a cysteine-rich domain and a cysteine-free spacer domain in the precise order in which they occur in the ADAMTS proteases
    • HOMOLOGY
    interspecies homolog to murine Adamtsl3
    Homologene
    FAMILY
  • ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may be having important functions in the extracellular matrix
  • might play a role in cell-matrix interactions or in assembly of specific extracellular matrices
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associate with ECM molecules through its TSR domains after secretion
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in colorectal carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS