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FLASH GENE

Symbol

ADAMTSL3

contributors: mct - updated : 07-11-2009

HGNC name	ADAMTS-like 3
HGNC id	14633

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_207517 30 - 7336 NP_997400 186 1691 - 2007 17597111

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive intestine large intestine colon     Homo sapiens   liver       highly Homo sapiens Hearing/Equilibrium ear outer       Reproductive female system breast       Homo sapiens Skin/Tegument skin         Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly

cells

System Cell Pubmed Species Stage Rna symbol Digestive epithelial cell Homo sapiens Endocrine islet cell (alpha,beta...) Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	immunoglobulin and thrombospondin domain
	one disintegrin-like domain
	one plac domain
	13 thrombospondin type 1 repeats (TSRs), arranged in two arrays separated by a region containing three immunoglobulin-like repeats
	a cysteine-rich domain and a cysteine-free spacer domain in the precise order in which they occur in the ADAMTS proteases

HOMOLOGY

interspecies

homolog to murine Adamtsl3

Homologene

FAMILY

ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	may be having important functions in the extracellular matrix
	might play a role in cell-matrix interactions or in assembly of specific extracellular matrices

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

associate with ECM molecules through its TSR domains after secretion

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in colorectal carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS