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FLASH GENE
Symbol NFIX contributors: mct - updated : 19-09-2017
HGNC name nuclear factor I/X (CCAAT-binding transcription factor)
HGNC id 7788
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one DWA//MH1 domain
  • a CTF/NF-I DNA-binding domain
  • two nuclear localization sequences, and both are required for full translocation to the nucleus, although one of them itself has a partial translocation ability
    • conjugated Other
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Nfix (99.8pc)
    homolog to rattus Nfix (100.00pc)
    Homologene
    FAMILY
  • nuclear factor one (NFI) gene family
    • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in DNA replication
  • recognizes and binds the palindromic sequence 5'- ttggcnnnnngccaa-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2
  • cooperating with activatory protein-1 by an unknown mechanism in astrocytes, which results in the expression of a subset of astrocyte-specific genes
  • play roles in patterning, glial development, cortical cell migration and axon guidance
  • essential for normal brain development and may be required for neural stem cell homeostasis
  • involved in the control of the expression of astrocytes markers at late stage of differentiation (PMID
  • activates the transcription of fetal specific genes such as CKM and ENO3 while repressing embryonic genes such as slow myosin
  • transcriptional switch from embryonic to fetal myogenesis
  • may be having a key role in chondrocyte differentiation, bone formation and in the endochondral ossification process
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms a complex with PKC theta and activates MEF2A
    • INTERACTION
    DNA binds DNA as a homodimer
    RNA
    small molecule
    protein
  • HSF1 bind to the NFIX promoter and repress its expression in a heat shock sensitive manner
  • under chronic heat shock, NFIX uses CGGBP1 and HMGN1 to get recruited to this promoter and in turn affects their binding to DNA
  • BBX is a downstream target of NFIX during development of the forebrain
    • cell & other
    REGULATION
    activated by PAX7 in fetal muscle
    Other inhibition of NFIX binding by c-jun plays a role in regulating levels of polyomavirus JC
    ASSOCIATED DISORDERS
    corresponding disease(s) MSMS , STOL1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS