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FLASH GENE

Symbol

NFIX

contributors: mct - updated : 19-09-2017

HGNC name	nuclear factor I/X (CCAAT-binding transcription factor)
HGNC id	7788

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002501 10 - 5576 NP_002492 - 441 - 1995 7590749

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain limbic system hippocampus   highly   brain forebrain cerebral lobe frontal predominantly   brain diencephalon thalamus   highly Reproductive female system ovary     highly   male system prostate     highly Urinary bladder       highly Visual eye lens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone     highly Muscular striatum skeletal   highly Nervous central     predominantly Nervous peripherous     predominantly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, fetal

Text	normally expressed prenatally during human brain development and skeletogenesis
	expressed in the developing telencephalon

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one DWA//MH1 domain
	a CTF/NF-I DNA-binding domain
	two nuclear localization sequences, and both are required for full translocation to the nucleus, although one of them itself has a partial translocation ability

conjugated

Other

mono polymer

homomer , dimer

HOMOLOGY

interspecies	homolog to murine Nfix (99.8pc)
	homolog to rattus Nfix (100.00pc)

Homologene

FAMILY

nuclear factor one (NFI) gene family

CATEGORY

DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	involved in DNA replication
	recognizes and binds the palindromic sequence 5'- ttggcnnnnngccaa-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2
	cooperating with activatory protein-1 by an unknown mechanism in astrocytes, which results in the expression of a subset of astrocyte-specific genes
	play roles in patterning, glial development, cortical cell migration and axon guidance
	essential for normal brain development and may be required for neural stem cell homeostasis
	involved in the control of the expression of astrocytes markers at late stage of differentiation (PMID
	activates the transcription of fetal specific genes such as CKM and ENO3 while repressing embryonic genes such as slow myosin
	transcriptional switch from embryonic to fetal myogenesis
	may be having a key role in chondrocyte differentiation, bone formation and in the endochondral ossification process

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

forms a complex with PKC theta and activates MEF2A

INTERACTION

DNA	binds DNA as a homodimer

RNA

small molecule

protein	HSF1 bind to the NFIX promoter and repress its expression in a heat shock sensitive manner
	under chronic heat shock, NFIX uses CGGBP1 and HMGN1 to get recruited to this promoter and in turn affects their binding to DNA
	BBX is a downstream target of NFIX during development of the forebrain

cell & other

REGULATION

activated by

PAX7 in fetal muscle

Other

inhibition of NFIX binding by c-jun plays a role in regulating levels of polyomavirus JC

ASSOCIATED DISORDERS

corresponding disease(s)

MSMS , STOL1

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS