basic FUNCTION
| functional modulator of the transcriptional activation function Wilms tumor suppressor gene (WT1) |
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required for the maturation of extramitochondrial Fe/S proteins (Srinavasan 2007) |
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apoptosome-activating protein  |
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in the CIA pathway, CIAO1 cooperates with CIAO2A, CIAO2B, and MMS19 targeting factors to form various complexes that mediate the dedicated maturation of specific Fe/S recipient proteins  |
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CIAO1 an essential component of the cytosolic iron-sulfur protein assembly (CIA) machinery, is crucial for Fe/S cluster insertion into RSAD2 and hence for RSAD2 antiviral activity  |