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FLASH GENE
Symbol BVES contributors: mct/npt - updated : 22-08-2008
HGNC name blood vessel epicardial substance
HGNC id 1152
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveesophagus   highly
Endocrineparathyroid   highly
Hearing/Equilibriumear   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text developing heart
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three transmembrane helices with an extracellular C terminus
  • cytoplasmic carboxyl terminal portion (amino acids 115
    • 358) contains the uncharacterized POPDC domain (23
    25)
    HOMOLOGY
    interspecies ortholog to murine Bves
    Homologene
    FAMILY
  • POP family of proteins containing three putative transmembrane domains
    • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • playing an important role in development of cardiac and skeletal muscles
  • involved in the regeneration of adult skeletal muscle
  • acting as a cell adhesion molecule in coronary vasculogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text
  • muscle development
  • heart development
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with GEFT, a GEF for Rho-family GTPases, and colocalizing in adult skeletal muscle
  • regulator of the RAC1 and CDC42 signaling
    • cell & other
    REGULATION
    Other regulated by PAX3 or PAX3-FOXO1A
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene detection of methylation of the gene in blood might have utility in monitoring and detecting tumor recurrence in early-stage non-small cell lung cancer after curative surgical resection
    Marker
    Therapy target
    ANIMAL & CELL MODELS